Bug spray is one of the cheapest things in a hiking kit, and one of the few that protects you from something worse than discomfort. Mosquitoes are the itch you notice. Ticks are the bite you don't, and on trails across the Northeast and upper Midwest they carry Lyme disease. A repellent that works on both, and doesn't wreck your gear, is worth thinking about for five minutes.
Most of the choice comes down to the active ingredient, not the brand. The CDC lists six that the EPA has registered as effective: DEET, picaridin, IR3535, oil of lemon eucalyptus, PMD and 2-undecanone. Everything on this page uses one of the first four, plus permethrin, which is a different kind of product. You spray it on your clothes, not your skin.
The eight below are ranked on how well they keep ticks and mosquitoes off for a day on the trail, what they do to your pack and jacket, how they feel on skin, and how they carry. My dad and I haven't run a lab test on any of them. The order comes from each label, the CDC and EPA guidance, Consumer Reports' 2025 ratings as reported, and what Amazon buyers say after using them.
The short version for most hikers is two products, not one: a picaridin or DEET repellent for your skin, and permethrin for your pants, socks and shirt. That combination is what the CDC recommends for ticks, and it's the setup the top three picks here add up to.